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Die aktuelle Corona-Krise ist für unsere Patientinnen und Patienten und deren Angehörige mit vielen Fragen verbunden. Daher haben wir hilfreiche Informationen auf unserer Sonderseite zusammengestellt. Wichtiger Hinweis: Bitte rufen Sie bei Schlaganfall- oder Herzinfarkt-Symptomen sowie bei allen anderen Notfällen unbedingt die 112 an - die Versorgung im Notfall ist in der Uniklinik RWTH ...
DC-autophagy contributes to HSK disease. In dendritic cells, autophagy is important for delivery and processing of antigens in the MHCII antigen presentation pathway and thereby promoting the activation of CD4 + T cells (36, 37).Since HSK is driven by CD4 + T cells, we hypothesized that DC-autophagy would contribute to HSK. To address this, we generated atg5 fl/fl CD11c-cre (referred to in ...
  • Jul 14, 2003 · The Importance of CD11b + Dendritic Cells in CD4 + T Cell Activation In Vivo : With Help from Interleukin 1 Akiko Iwasaki Department of Epidemiology and Public Health and Immunobiology, Yale University School of Medicine, New Haven, CT 06520
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    IRF4 Transcription Factor-Dependent CD11b + Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses. Andreas Schlitzer, Naomi McGovern, Pearline Teo, Teresa Zelante, Koji Atarashi, Donovan Low, Adrian W.S. Ho, Peter See, Amanda Shin, Pavandip Singh Wasan, Guillaume Hoeffel, Benoit Malleret, Alexander Heiseke, ...
    Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate therapeutic approaches of overcoming such resistance by examining the differential microenvironmental response to RT.
  • Of note, Langerhans cells share properties with both MPs and dendritic cells (e.g. self-renewal and T cell stimulation), making them an unclassified cell type (i.e. neither MP nor dendritic cell) (Doebel et al., 2017). In terms of their developmental origins, both Langerhans cells and cutaneous MPs are highly heterogeneous.
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    Blood contains many types of cells, including many immune system components. Immune cells used to be characterized by marker-based assays, but now classification relies on the genes that cells express. Villani et al. used deep sequencing at the single-cell level and unbiased clustering to define six dendritic cell and four monocyte populations. This refined analysis has identified, among ...
    CDP: Common Dendritic Cell Progenitor pDC: Plasmacytoid DC LC: Langerhans Cell: cDC1: Conventional/Classical Dendritic Cell 1 or CD8a + DC. Human CD141 DCs are an equivalent of cDC1 cells in mice. cDC2: Conventional/Classical Dendritic Cell 2 or CD11b + DC. Human CD1c DCs are an equivalent of cDC2 cells in mice.
  • Of note, Langerhans cells share properties with both MPs and dendritic cells (e.g. self-renewal and T cell stimulation), making them an unclassified cell type (i.e. neither MP nor dendritic cell) (Doebel et al., 2017). In terms of their developmental origins, both Langerhans cells and cutaneous MPs are highly heterogeneous.
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    However, the CD11b + cell profiles were different between the two, such that CD11c + DC fractions were higher and CD244 + Ly6C low Ly6G hi PMN-MDSC fractions were lower in the in vitro MyD88-KO CD11b + cells (12.20% and 26.50%, respectively) than in the WT counterparts (5.3% and 40.0%, respectively; Fig. 7C).
    CD103 + CD11b + dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGFβR1) has an indispensable, cell intrinsic role in the development of these cells. Deletion of Tgfbr1 results in markedly fewer intestinal CD103<SUP>+</SUP>CD11b<SUP>+</SUP> DCs and a reciprocal increase in ...
  • A review of the Antibody Labeling of CD11b+ Dendritic Cells in Mouse Lungs . Unbiased reviews by scientists available at Biocompare.com.
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    Aug 04, 2016 · Plantinga M, et al. Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity . 2013;38(2):322–335. View this article via: PubMed CrossRef Google Scholar Redundancy mode sso
    After exclusion of dead cells, CD3 + and CD19 + T and B cells, respectively, conventional dendritic cells (cDCs) were identified as MHC II + CD11c high cells. Within the cDC population, two main subsets were detectable on the basis of the differential expression of CD11b and CD8α.
  • T-helper 2 (Th2) cell responses defend against parasites. Although dendritic cells (DCs) are vital for the induction of T-cell responses, the DC subpopulations that induce Th2 cells in the intestine are unidentified.
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    Phenotype In mice. In mouse models, MDSCs are found as myeloid cells expressing high levels of CD11b (a classical myeloid lineage marker) and GR1 (granulocytic marker).The GR1 marker is made up of two cell membrane molecules, Ly6C and Ly6G, and according to their relative expression levels murine MDSCs are further classified into two subtypes, monocytic and granulocytic.Control trophy guide
    Organ stroma‐educated CD11b high regulatory dendritic cells could down‐regulate T cell response, contributing to tolerance induction and resulting in the attenuation of asthma and hepatitis. 14-17 However, the biological significance of high CD11b expression in these regulatory dendritic cells remains unclear. Therefore, the regulation of ...
  • Immunity Article IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses Andreas Schlitzer,1,9 Naomi McGovern,2,9 Pearline Teo,1 Teresa Zelante,1 Koji Atarashi,3 Donovan Low,1 Adrian W.S. Ho,1 Peter See,1 Amanda Shin,1 Pavandip Singh Wasan,1 Guillaume Hoeffel,1 Benoit Malleret,1 Alexander Heiseke,4 Samantha Chew,1 Laura Jardine,2 ...
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    CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic ...Rts 1 program uzivo
    We find that the ST313 isolate D23580 hyperdisseminates from the gut to systemic sites, such as the mesenteric lymph nodes (MLNs), via CD11b(+) migratory dendritic cells (DCs). This hyperdissemination was facilitated by the loss of sseI, which encodes an effector that inhibits DC migration in gastroenteritis-associated isolates.
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Monocytes can further differentiate into tissue macrophages, dendritic cells and osteoclasts, which are influenced by different types of cytokines [18,19]. They are commonly defined by cell surface expression of CD11b and CD14 in humans .
Dendritic cells; hypersensitivity pneumonitis; innate immunity; nontuberculous mycobacteria; Toll-like receptors; Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is a granulomatous inflammatory lung disease that represents an immunological response to inhalation of airborne aetiological agents [1-3].Over 300 agents have been reported as causative, but avian ...
Early metastases were associated with dense networks of CD11b+CD11c+MHC-II+CD24+CD64lowF4/80low dendritic cells (DC), which developed from monocytes in response to tumor-released GM-CSF. These cells uniquely expressed MGL2 and PD-L2 in the metastatic microenvironment and preferentially induced the expansion of T regulatory cells (Treg) in vitro ...
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Mar 11, 2014 · CD11b + Migratory Dendritic Cells Mediate CD8 T Cell Cross-Priming and Cutaneous Imprinting after Topical Immunization Suzanne T. Nizza, Affiliations Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston ...
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The CD11c Ϫ cells were stained with anti-mouse CD11b mAb (Mac-1 ␣ , MACS-anti-CD11b, clone M1/70) and purified with Au-toMACS as well.For the purification of CD8 ␣ Ϫ and CD8 ␣ ϩ DCs or of CD11b high DCs, spleen cells were stained with MACS-anti-CD11c, PE-anti-CD11c (HL-3 clone) and anti-CD16-32 antibodies and FITC-anti-CD8␣ (53-6.7 ...
Dendritic cells (DC) and cytokines that expand myeloid progenitors are widely used to treat cancer. Here, we show that CD11c+DEC205+ DCs coexpressing α-smooth muscle actin and VE-cadherin home to perivascular areas in the ovarian cancer microenvironment and are required for the maintenance of tumor vasculature. Consequently, depletion of DCs in mice bearing established ovarian cancer by ...
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Sep 16, 2020 · Interleukin-2 (IL-2) is an immunostimulatory cytokine that is being tested as an anticancer therapy due to its ability to activate T cells and natural killer cells. Unexpectedly, Raeber et al . discovered that IL-2 can also activate dendritic cells, an entirely different type of cells involved in antitumor immunity. The authors analyzed data from a clinical trial in human patients being ...

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Products for Isolating CD14+ Monocytes and Generating Monocyte-derived Dendritic Cells In Vitro 1) The MagCellect™ Human CD14+ Cell Isolation Kit is Used to Isolate Human CD14+ Monocytes The MagCellect™ Human CD14 + Cell Isolation Kit is designed to separate CD14 cells from other human leukocytes via a positive selection principle. The cells of interest are tagged with a biotinylated anti ...Here we examined acute effects of TGFβ1 overproduction by keratinocytes on skin dendritic cells (DCs). TGFβ1 induction for 2 and 4 days increased the numbers and CD86 expression of B220 + plasmacytoid DCs (pDCs) and CD207 + CD103 +, CD207 - CD103 - CD11b +, and CD207 - CD103 - CD11b - dermal DCs (dDCs) in skin-draining lymph nodes (SDLNs).

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Ocular infection with herpes simplex virus type 1 (HSV-1) frequently leads to recurrent infection, which is a major cause of corneal scarring. Thus, the prevention of the establishment of latency should be a primary goal of vaccination against HSV-1. To this end, we have examined the contribution of dendritic cells (DCs) to the efficacy of a vaccine against ocular HSV-1 infection.

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Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus Judith-Mira Pohl,1 Sebastian gutweiler,1,2 Stephanie thiebes, 1 Julia K Volke,1 ludger Klein-Hitpass,3 Denise Zwanziger,4 Matthias gunzer,1 Steffen Jung,5

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